Definition:
In basophilic stippling, fine, basophilic dots are distributed over the entire erythrocyte. Like polychromasia, this is an indication of RNA remnants that lend a basophilic color to the cell.
Occurrence:
Basophilic stippling occurs with increased erythropoiesis as is typical in hemolysis or after replacement therapy in nutritional deficiency (iron, vitamin B12). A coarse basophilic stippling is observed in lead poisoning.
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