Definition:
Spherocytes are ball-shaped erythrocytes. Since they are usually small, they are also called microspherocytes. Unlike microcytes, they have no central pallor and usually have an elevated MCHC. Spherocytes have a reduced life span since they are mechanically-fragile.
Occurrence:
Spherocytes occur naturally in hereditary spherocytosis (a membrane defect) and acquired in hemolytic anemia (loss of cell membrane by immune mechanismes in the RES).
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