Appearance:
Promyelocytes represent the second developmental stage of granulopoiesis between myeloblasts and myelocytes. Cells vary in size from 15 - 25 µm, have a distinct basophilic cytoplasm with coarse, bright red primary (azurophilic) granules, and often have a perinuclear halo. Nuclei range in shape from round to oval and are usually eccentric, with fine chromatin and several nucleoli.
Occurrence:
- Severe bacterial infections with leukemoid reaction.
- Chronic myelocytic leukemia and myelofibrosis with extramedullary hematopoiesis.
- Acute myelocytic leukemias.
- Acute promyelocytic leukemia.
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