Synonym:
Stimulated lymphocytes.
Appearance:
Atypical lymphocytes can vary widely in size, form and shape. They are larger than normal lymphocytes and have a large volume of light to dark basophilic cytoplasm that has a more intense color along the cell membrane. Vacuoles and azure granules may also be present. The nucleus is often kidney-shaped. The chromatin is finer than in small lymphocytes and often has one or more nucleoli. Atypical lymphocytes can not always be clearly identified and are often confused with leukemic blasts by those who are inexperienced.
Occurrence/Presence:
- Viral infections such as infectious mononucleosis, cytomegalovirus and primary HIV infection
- Toxoplasmosis
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