Definition:
Macrocytosis is the frequent occurrence of macrocytes. These are erythrocytes with a diameter of more than 9 µm and a MCV < fl. Oval macrocytes are typically found in megaloblastic anemia.
Occurrence:
Macrocytosis occurs when abnormal erythropoiesis is present as in alcohol consumption, liver disease, during use of cytotoxic (e.g. azathioprine, hydroxyurea) or virostatic drugs (e.g. zidovudine), in megaloblastic anemia through a vitamin B12 and/or folic acid deficiency as well as in myelodysplastic syndromes.
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